MarScreen

MarScreen®

MarScreen is the bead method for the detection of sperm-reactive IgA, IgG, and IgM antibodies.

Features

2-component kit
direct method performed on fresh unprocessed semen
built-in positive control
can be performed and analyzed in less than 10 minutes
uniform colored beads for easy-to-read results
improvement over SpermMarTM
only reagents available that detect IgA and IgM antibodies using the
Mixed Agglutination Reaction
competitively priced

Background

There is considerable evidence that antibodies directed against sperm surface antigens exert a fertility-reducing effect. When antisperm antibodies are present, they bind to the surface of the sperm. Such sperm-bound antibodies may impair sperm movement, penetration of the cumulus and/or zona pellucida, the acrosome reaction, interaction of sperm and egg as well as identify the sperm for destruction by the immune system. It has also been suggested that sperm antibodies may exert an embryotoxic effect. Finally, there is evidence that antibody concentration is correlated directly with the severity of sperm functional impairment and inversely with potential fertilizability. For these reasons, many reproductive specialists screen sperm and/ or serum for anti-sperm antibodies before before choosing an appropriate Assisted Reproductive Technology.

Package Insert MarScreen IgA
Package Insert MarScreen IgG
Package Insert MarScreen IgM

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