Bioscreen Assay Kits

Bead Method for the Detection of Sperm-Reactive IgA, IgG, and IgM Antibodies
There is considerable evidence that antibodies directed against sperm surface antigens exert a fertility-reducing effect. When antisperm antibodies are present, they bind to the surface of the sperm. Such sperm-bound antibodies may impair sperm movement, penetration of the cumulus and/or zona pellucida, the acrosome reaction, interaction of sperm and egg as well as identify the sperm for destruction by the immune system. It has also been suggested that sperm antibodies may exert an embryotoxic effect. Finally, there is evidence that antibody concentration is correlated directly with the severity of sperm functional impairment and inversely with potential fertilizability.

For these reasons, many reproductive specialists screen sperm and/or serum for anti-sperm antibodies before choosing an appropriate Assisted Reproductive Technology.

LeucoScreen™

LeucoScreen Cytochemical Stain For Detecting Granulocytes in Semen

High white blood cell concentrations in semen, referred to as leucocytospermia, have been associated with genital tract infection and poor semen quality. The predominant white blood cell type is the polymorphonuclear granulocyte, normally comprising 50 - 80% of total seminal white blood cells. This subpopulation can be detected using a peroxidase test which visualizes the enzyme peroxidase in cells.

The WHO Manual classifies the detection of white blood cells in semen as a standard, rather than an optional, method for the examination of human semen.

Sperm Antibody(IgG) and (IgA/IgG) Controls

Sperm Antibody (IgA/IgG) Controls Positive Serum containing antisperm antibodies of the IgA and IgG subclasses and Negative Serum with no detectable antisperm antibodies.

Sperm Antibody (IgG) Controls Positive Serum containing antisperm antibodies of the IgG subclass and Negative Serum with no detectable antisperm antibodies

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